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In previous studies, orforglipron reduced body weight by 12.4% and improved cardiometabolic risk factors after 72 weeks in adults with obesity without diabetes

Impressively, both of these approaches have achieved greater weight loss than targeting each receptor alone, 40 -42 though there is ambiguity in understanding how this works and any direct effects on the kidney likely rely on GLP-1 signaling

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GLP-1 receptor agonists work by targeting GLP-1 receptors: increasing insulin, decreasing glucagon and delaying gastric emptying 2

Table 2 presents clinical and biochemical characteristics of participants grouped by TSH